San Francisco Frontiers - Covid lab leak theory needs more research: WHO advisors

In its first preliminary report, the so-called Scientific Advisory Group for the Origins of Novel Pathogens (SAGO) stressed that it had no conclusive findings on the origins of the virus behind the worst global pandemic in a century.

The team of 27 experts was set up by the WHO last year to produce a new global framework for studies into emerging pathogens with the potential of sparking epidemics or pandemics.

It has been tasked with providing an independent assessment on a way forward in the thorny investigation into the origins of the SARS CoV-2 virus that causes Covid-19 disease.

"There are key pieces of data that are not yet available for a complete understanding of how the Covid-19 pandemic began," they acknowledged in their report, stressing that a range of further studies were needed "to follow up on several gaps in our knowledge".

- 'Zoonotic transmission' -

The experts evaluated a wide range of existing research, including the findings of a joint WHO-China scientific mission last year, as well as more recent published and unpublished studies.

They seemed to back a key finding by the joint mission that the virus most likely jumped from bats to humans via an intermediate animal, so-called zoonotic transmission.

"The strongest evidence is still around zoonotic transmission," SAGO chair Marietjie Venter told reporters, although the original host, intermediate hosts or how the virus had jumped to humans have not been identified.

But while the joint mission had deemed a competing theory that the virus may have escaped due to a laboratory incident was "extremely unlikely" and proposed no further investigation into that hypothesis, the SAGO team insisted that this issue too required further study.

Among a long line of studies requested, the team stressed that "it remains important to consider all reasonable scientific data that is available either through published or other official sources to evaluate the possibility of the introduction of SARS-CoV-2 into the human population through a laboratory incident".

The issue is highly controversial, and SAGO acknowledged that three members of the team, from China, Russia and Brazil, had objected to including the recommendation.

- 'Need to be open-minded' -

Venter told reporters it was important to be open to various hypotheses.

"Having it in the report doesn't say that that's definitely what we think it is," she said, insisting that it merely means "we are open to scientific data... so if anything comes up that's new, we will not ignore it".

"We need to be open-minded and cover all the hypotheses, including that one," her co-chair Jean-Claude Manuguerra agreed, stressing that so far there had been no real investigation into the lab leak theory.

Among other things, the experts said access was needed to staff and data from labs both in China and elsewhere that work with coronaviruses, including SARS-CoV-2, to assess biosafety and biosecurity practices.

This could be tricky, especially in the case of China, which has so far pushed back against suggestions of fresh international missions to the country.

WHO chief Tedros Ahanom Ghebreyesus insisted that it was vital that the scientific work to determine Covid's origins "be kept separate from politics".

In a briefing to member states, he said the UN health agency would strive to follow SAGO's advice, emphasising that "all hypotheses must remain on the table until we have evidence that enables us to rule certain hypotheses out".

"The longer it takes, the harder it becomes. We need to speed up and act with a sense of urgency."

J.Martinez--SFF